If your asking I'm assuming you cannot afford both. I would go with the bow of destruction that way you are able to single target with it and also AoE team hunt with diamond arrows. I cannot stress enough the importance of AoE hunting with RP's they added it to the game and we need to fully embrace it.
As far as imbues go, I personally like the tier 2 mana leech, life leech, and crit.
Again in my own personal opinion I have a rift bow and a bow of destruction fully imbued, I use the BoD for large team hunts with friends and Rift when I hunt solo AoE. My third bow I use for questing or beastiary is my umbral bow with only crit imbue. All in all it is awesome to have multiple weapons in your arsenal!
Lastly do not worry too much on your imbuements while in a hunt as long as your staying profitable during your hunts the imbuements will pay off in the long run. Happy Hunting Bro!