I would say, that it depends on your vocation and level. My friend ED 1050+ couldn't kill Lisa solo, but he was very very close.
We need to remember, that Lisa is strong to ice element, which makes ED the worst possible vocation to face her. I'm sure, that high level RPs or EKs are able to kill her solo. Especially using weapon with energy damage.
Imagine high level EK, like 1000+ or even higher with good skills and Soulmaimer
You see a soulmaimer (Atk:10 physical + 47 energy, Def:35, club fighting +5, critical hit chance 10%, critical extra damage +10%).
Imbuements: (Empty Slot, Empty Slot, Empty Slot).
It can only be wielded properly by knights of level 400 or higher.
It weighs 89.00 oz.
I think that he would be able to kill her. Other thing is that it might be problematic.