<p><u><strong>No</strong></u>, if you're in a fight (have the logout block icon <img alt="" src="https://vignette.wikia.nocookie.net/tibia/images/f/f7/Logout_Block_Icon.gif/revision/latest?cb=20171122235844&path-prefix=en"> active in your status bar) you can't buy runes or potions from the store. The icon will disappear if you've not been in a fight for the last 60 seconds.</p><p>Note that even if you enter protection zone and the logout block icon <img alt="" src="https://vignette.wikia.nocookie.net/tibia/images/f/f7/Logout_Block_Icon.gif/revision/latest?cb=20171122235844&path-prefix=en" style="height:9px; width:9px"> isn't active, you still can't buy any potions/runes from the shop and need to wait 60 seconds from when you were last in a fight. If you'd like to instantly buy potions/runes then the you could go to protection zone and relog your character, and after that you would be able to buy it.</p><p></p><p><em><span it.<br><br><img alt="" src="https://www.tibiaqa.com/?qa=blob&qa_blobid=1734977391834699693" style="height:191px; width:600px"><br><span style="font-size:12px">This is the <em>warning</em> text you will recieve if you're trying to buy potions/runes if you've been in a fight within the last 60 seconds.</span></p><p></p><p><em><span style="font-size:10px">Picture and some information from <a rel="nofollow" href="https://tibia.fandom.com/wiki/Logout_Block">TibiaWiki</a>.</span></em></p>