The Nemesis bosses which spawn randomly every few days are often sought after by boss hunters, either for completing the Bosstiary or acquiring rare loot which they drop.
For this reason you will often see these spawns with players coming in, or lower level characters logging in and out at the spawn location.
This often raises a question, whether these players may be unintentionally delaying or blocking the boss's spawn by their presence.
From my own experience, I encountered these bosses inside their spawn during the very moment they spawned. This means you cannot block their spawn. They act similar to a raid (When a message appears informing of monsters spawning next to a city, for example). A raid cannot be blocked, and the monsters instead spawn around the players at the location.