You already mentioned one of the bonus.
Grants a defense bonus against Night Harpy for 4 hours.
For that purpose, I bought a bottle
at the market to give you the exact amount of defense.
Gear set used:
Test done on a single Harpy Nest respawn:

Without drinking the bottle, in 4 minutes.
Total damage: 75,164
Max-DPS: 1,711

Impact analyser:
For this purpose, to see if we have an attack bonus, I only attacked with the wand:

Now, after drinking the bottle, I tested again for 4 minutes, same gear, same place, only 1 harpy.

Total damage received: 55,685
Max-DPS: 1,125

Impact analyser
Here I attacked less time to avoid killing the Harpy, but just seeing the Max DPS I did, I can realize there is no change in damage given to the Harpy.

Conclusion:
Comparing the two analyses:
Total Damage:
- Image 1: 75,164
- Image 2: 55,685
- Difference: 19,479 (~25.9% more in Image 1)
Max-DPS:
- Image 1: 1,711
- Image 2: 1,125
- Difference: 586 (~52.1% more in Image 1)
Max-DPS could be a range of luck, but the total damage is clear ; this bottle gives you a 25% reduction in damage from the Harpies.
Extra information
As well, if you drink that item 20 times, you get the achievement.t Stagmeister
Sources:
For the achievement info: https://tibia.fandom.com/wiki/Stagmeister